AZ-876 |CAS:898800-26-5 Probechem Biochemicals

Chemical Structure : AZ-876

CAS No.: 898800-26-5

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AZ-876 (AZ876;AZ 876)

货号: PC-45444Not For Human Use, Lab Use Only.

AZ-876 (AZ876) is a potent, highly selective LXR agonist with Ki/EC50 of 7/6 nM and 11/73 nM for hLXRα and hLXRβ respectively.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

AZ-876 (AZ876) is a potent, highly selective LXR agonist with Ki/EC50 of 7/6 nM and 11/73 nM for hLXRα and hLXRβ respectively.
AZ-876 is a more potent binder and activator of LXRα and LXRβ than GW3965.
AZ-876 is highly selective against FXR, RXR, TRα, TRβ etc.
AZ-876 reduces lesion area, and strongly decreases lesion area, lesion number and severity in vivo.
AZ-876 protects against pathological cardiac hypertrophy and fibrosis without lipogenic side effects in mice.

物理化学性质&存储条件

分子量	439.5704
分子式	C24H29N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 2.6 mg/mL
Chemical Name/SMILES	3(2H)-Isothiazolone, 2-(1,1-dimethylethyl)-5-phenyl-4-[[4-(1-piperidinyl)phenyl]amino]-, 1,1-dioxide

参考文献

1. van der Hoorn J, et al. Br J Pharmacol. 2011 Apr;162(7):1553-63.

2. Cannon MV, et al. Eur J Heart Fail. 2015 Mar;17(3):273-82.

AZ-876 (AZ876;AZ 876)

生物&药学活性

物理化学性质&存储条件

参考文献

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AZ-876 (AZ876;AZ 876)

生物&药学活性

物理化学性质&存储条件

参考文献

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