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首页-小分子抑制剂&激动剂-GPCR-Angiotensin Receptor-AVE-0991
AVE-0991

Chemical Structure : AVE-0991

CAS No.: 304462-19-9

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AVE-0991 (AVE0991)

货号: PC-21225Not For Human Use, Lab Use Only.

AVE 0991 is a potent, selective nonpeptide and orally active angiotensin-(1-7) receptor Mas agonist, displaces the binding of 125I-Ang-(1-7) in Mas-transfected monkey kidney cells (COS) cells with IC50 of 47.5 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AVE 0991 is a potent, selective nonpeptide and orally active angiotensin-(1-7) receptor Mas agonist, displaces the binding of 125I-Ang-(1-7) in Mas-transfected monkey kidney cells (COS) cells with IC50 of 47.5 nM.

物理化学性质&存储条件

分子量 580.72
分子式 C29H32N4O5S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-[(Ethylamino)carbonyl]-3-[4-[(5-formyl-4-methoxy-2-phenyl-1H-imidazol-1-yl)methyl]phenyl]-5-(2-methylpropyl)-2-thiophenesulfonamide

参考文献

1. Pinheiro SV, et al. Hypertension. 2004 Oct;44(4):490-6.

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