AMG-176 |CAS:1883727-34-1 Probechem Biochemicals

Chemical Structure : AMG-176

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AMG-176 (AMG 176;AMG176)

货号: PC-70089Not For Human Use, Lab Use Only.

AMG-176 (AMG176) is a novel, potent and selective Mcl-1 inhibitor that binds with high affinity (Ki=0.06 nM) and selectivity to the BH3-binding groove of Mcl-1.

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生物&药学活性

AMG-176 (AMG176) is a novel, potent and selective Mcl-1 inhibitor that binds with high affinity (Ki=0.06 nM) and selectivity to the BH3-binding groove of Mcl-1.
AMG-176 disrupts the interaction between Mcl-1 and Bak, leading to downstream activation of the intrinsic apoptosis pathway in a cell based split-luciferase complementation assay (IC50=43 nM).
AMG-176 shows robust anti-tumor activity in Mcl-1 dependent cancer models.
AMG-176 is orally bioavailable.

物理化学性质&存储条件

分子量	613.21
分子式	C33H41ClN2O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Spiro[5,7-etheno-1H,11H-cyclobut[i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-2(3H),1'(2'H)-naphthalen]-8(9H)-one, 6'-chloro-3',4',12,13,16,16a,17,18,18a,19-decahydro-16-methoxy-11,12-dimethyl-,10,10-dioxide, (1'S,11R,12S,14E,16S,16aR,18aR)-

参考文献

1. Sean R. Caenepeel, et al. AACR Annual Meeting 2017; April 1-5, 2017.
2, Caenepeel S, et al. Cancer Discov. 2018 Dec;8(12):1582-1597.

AMG-176 (AMG 176;AMG176)

生物&药学活性

物理化学性质&存储条件

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AMG-176 (AMG 176;AMG176)

生物&药学活性

物理化学性质&存储条件

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