ACT 709478 |CAS:1838651-58-3 Probechem Biochemicals

Chemical Structure : ACT 709478

CAS No.: 1838651-58-3

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ACT 709478 (Apinocaltamide, ACT709478)

货号: PC-62008Not For Human Use, Lab Use Only.

Apinocaltamide (ACT 709478) is a potent, selective, orally-bioavailable, brain penetrant T-type calcium channel blocker with IC50 of 6.4, 18, and 7.5 nM for Cav3.1, Cav3.2, and Cav3.3 channels respectively.

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10 mg	￥2280	In stock
25 mg	￥3880	In stock
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生物&药学活性

Apinocaltamide (ACT 709478) is a potent, selective, orally-bioavailable, brain penetrant T-type calcium channel blocker with IC50 of 6.4, 18, and 7.5 nM for Cav3.1, Cav3.2, and Cav3.3 channels respectively.
ACT 709478 displays >100-fold selectivity over Cav1.2 channels.
ACT 709478 shows a significant decrease of the seizure severity in vivo (100 mg/kg, p.o.).

物理化学性质&存储条件

分子量	425.415
分子式	C22H18F3N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1-((5-Cyanopyridin-2-yl)methyl)-1H-pyrazol-3-yl)-2-(4-(1-(trifluoromethyl)cyclopropyl)-phenyl)acetamide

参考文献

1. Bezençon O, et al. J Med Chem. 2017 Nov 8. doi: 10.1021/acs.jmedchem.7b01236.

ACT 709478 (Apinocaltamide, ACT709478)

生物&药学活性

物理化学性质&存储条件

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ACT 709478 (Apinocaltamide, ACT709478)

生物&药学活性

物理化学性质&存储条件

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