Mirin |CAS:299953-00-7 Probechem Biochemicals

Chemical Structure : (E)-Mirin

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(E)-Mirin

货号: PC-61927Not For Human Use, Lab Use Only.

Mirin is a small molecule that specifically inhibits endonuclease, but not exonuclease activity of MRE11, inhibits MRN-mediated ATM activation (inhibition of H2AX phosphorylation) with IC50 of 66 uM.

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生物&药学活性

(E)-Mirin is a small molecule that specifically inhibits endonuclease, but not exonuclease activity of MRE11, inhibits MRN-mediated ATM activation (inhibition of H2AX phosphorylation) with IC50 of 66 uM.
(E)-Mirin inhibits MRN/DSB-mediated ATM activation without affecting ATM protein kinase activity.
(E)-Mirin inhibits the MRN-dependent autophosphorylation of ATM at Ser1982 in response to DSBs.
(E)-Mirin inhibits dsDNA and resection in A549 cells with IC50 of 200-300 uM, abolishes the G2/M checkpoint and homology-directed DNA repair in mammalian cells.

物理化学性质&存储条件

分子量	220.3
分子式	C10H8N2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-amino-5-[(4-hydroxyphenyl)methylene]-4(5H)-thiazolone

参考文献

1. Shibata A, et al. Mol Cell. 2014 Jan 9;53(1):7-18.

2. Hengel SR, et al. Cell Chem Biol. 2017 Sep 21;24(9):1101-1119.

(E)-Mirin

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物理化学性质&存储条件

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(E)-Mirin

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物理化学性质&存储条件

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